May 4, 2006 (CIDRAP News) – In an effort to modernize vaccine production while preparing for an influenza pandemic, the US government today awarded five contracts totaling more than $1 billion to develop cell-based technologies for making flu vaccines.The awards to five pharmaceutical companies are intended to help create an alternative to growing flu vaccines in eggs, the time-consuming production method used since the 1950s, and boost US production capacity. The money comes from $3.3 billion Congress appropriated last December for pandemic preparations by the Department of Health and Human Services (HHS).”Today, we’re taking a step closer to preparedness by investing more than $1 billion to develop vaccines more quickly and to produce them here in the United States,” HHS Secretary Mike Leavitt said in a news release.HHS listed the vaccine makers and their contract awards as follows: GlaxoSmithKline, $274.75 million; MedImmune, $169.6 million; Novartis Vaccines & Diagnostics, $220.51 million; DynPort Vaccine, $40.97 million; and Solvay Pharmaceuticals, $298.59 million.The announcement comes a day after the Bush administration released a 228-page plan for implementing its flu pandemic strategy. One of the administration’s goals is to develop the capacity for domestic production of enough vaccine for every American within 6 months of the emergence of a pandemic.It takes about 6 months to grow seasonal flu vaccines in eggs, and the eggs must be ordered well in advance. Growing vaccines in laboratory cell cultures promises to be a somewhat faster and much more flexible approach. The method is already used for a number of other vaccines, such as polio, hepatitis A, and chickenpox.”Our current capacity of egg-based influenza vaccine production is not sufficient to meet increased demands during an emergency,” said Leavitt. “Accelerating the development of this vaccine technology and creating domestic capacity are critical to our preparedness efforts.”With cell-based production, companies can skip the step of adapting the virus strains to grow in eggs, the HHS statement said. In addition, the method will make it possible to meet increased needs in case of a shortage or pandemic, since cells can be frozen in advance and large volumes can be grown quickly, officials said.Cell-based methods also sidestep the risk of loss of egg supplies because of various poultry diseases. Such methods also eliminate the drawback that people who are allergic to eggs can’t receive vaccines grown in eggs.The HHS announcement didn’t give details on the contract requirements or timetables, but the companies offered some information in news releases. All said the contracts are for 5 years.GlaxoSmithKline said it will use the award to speed the development of new cell-based seasonal and pandemic flu vaccines and to increase cell-culture manufacturing capability at the company’s plant in Marietta, Pa. The company said that in addition to using the HHS funds, it will continue plans to invest more than $100 million in cell-culture production at the Pennsylvania plant.MedImmune, maker of the intranasal vaccine FluMist, said it will use the contract to develop cell-based flu vaccines involving the same technology as FluMist, which uses a weakened live virus. The company, based in Gaithersburg, Md., said it plans to build “a cell-based facility in the Untied States that can produce at least 150 million doses within six months of notification of an influenza pandemic.”Swiss-based Novartis, like MedImmune, cited a goal of being able to produce 150 million doses of vaccine in a US facility within 6 months after declaration of a pandemic. The HHS contract will support product development and the design and testing of equipment.Last fall Novartis launched a US phase 1-2 study of an investigational cell-culture-derived flu vaccine, the company said. The firm expects to file for European approval of that vaccine, made in Marburg, Germany, later this year.DynPort Vaccine Corp. (DVC), a subsidiary of Computer Sciences Corp., said it is collaborating with Baxter Healthcare Corp. to develop cell-based flu vaccines. The firm said its HHS contract is worth $242.5 million, whereas the HHS announced listed the amount at $40.9 million.HHS spokesman Marc Wolfson explained that the amount in excess of $40.9 million is conditional on additional appropriations as well as meeting the requirements of the contract. Wolfson is with the HHS Office of Public Health Emergency Preparedness in Washington.DynPort said its contract supports, in addition to cell-based vaccine development, the pursuit of licensing for two flu vaccine candidates: “a split virus vaccine” for seasonal flu and a modified whole-virus vaccine for H5N1 avian flu.Solvay, based in Brussels, Belgium, said its HHS contract covers the development of new cell-based flu vaccine and “the development of a master plan to manufacture, formulate, fill and package annual and pandemic influenza vaccines in a new U.S.-based facility.””Our expertise gained from building our new commercial scale, cell-based influenza vaccine manufacturing facility in The Netherlands provides a strong foundation for the development of a similar facility in the U.S.,” said Werner Cautreels, PhD, the company’s CEO.In April 2005, HHS awarded Sanofi Pasteur a $97 million contract to develop a cell-based flu vaccine. The company was the first to receive a federal contract for commercial scale use of new flu vaccine technology, the agency said.See also:Jun 27, 2005, CIDRAP News story “Momentum builds for cell-culture flu vaccines”Apr 4, 2005, CIDRAP News story “HHS funds development of cell-based flu vaccines”
From the front!The record residential sale for Mermaid Waters had previously been held by a five-bedroom four-bathroom home that sold for $2.9 million earlier this year. The house is on a huge 1900sq m at 51-53 Portobello Rd.REIQ Gold Coast zone chair John Newlands said Mermaid Waters was feeling the effects of a surging Mermaid Beach. There is no shortage of space.More from news02:37Purchasers snap up every residence in the $40 million Siarn Palm Beach North2 hours ago02:37International architect Desmond Brooks selling luxury beach villa22 hours agoSam Guo and Julia Kuo of Ray White Broadbeach-Mermaid Waters handled the sale.“A local Chinese buyer bought it,” Mr Guo said. “It was all about the size and history of the property as well as the spectacular renovation. “ 29-31 Cessnock Close, Mermaid Waters.The vendors undertook a major renovation, transforming the house into a modern masterpiece.The two-storey residence is set out over a double 1633sq m block and has five bedrooms, seven bathrooms, multiple living areas, pool, tennis court and cinema. 29-31 Cessnock Close, Mermaid Waters sold for $3.25 million, smashing the suburb record.A GRAND Hamptons-inspired Mermaid Waters mansion has sold for $3.25 million, smashing the suburb record.The luxury waterfront property at 29-31 Cessnock Close was originally built by Gold Coast identity Jenny Wong. Imagine cooking in this kitchen.It was a dated house but the vendors have transformed it into a beautiful home.”He said there weren’t many houses comparable in size and structure in Mermaid Waters. “That’s why it got such a great price.” Enjoy a dip in the pool or play a game of tennis.“Not everyone can afford to live on the beachfront but will pay a high price to live nearby,” he said.“It also comes down to the lifestyle aspect.“There’s lots of nice cafes and restaurants popping up. People used to have to travel to go to them but now they are on their doorstep.”
GUILTY VERDICT. Representative Toto Mangudadatu arrives at Camp Bagong Diwa in Taguig on December 19, 2019, for the verdict on the decade-long Ampatuan trial. Photo by Rappler “Kung hindi nakadroga sina Unsay, kung hindi nakadroga silang magkakapatid pati ‘yung tatay, gagawin ba nila ‘yun? Walang iiwan? Gagalawin ba nila ‘yung mga babae? Malaya naman tayo eh, nasa demokrasya tayo bakit ginawa ‘yun?” he added. “Malaking mensahe na maipakita sa mga kababayan natin hindi lang sa Maguindanao kundi sa buong Pilipinas, buong mundo na tama na ‘yung power na pinapasobra, ‘yun bang palagay nila nakatitulado sa kanila ‘yung power na ‘yun hindi na mawawala,” he added. Mangudadatu lost his wife and sisters, along with other political supporters, in the November 2009 massacre. At that time, he was planning to run against the Ampatuan clan for the gubernatorial post in Maguindanao for the 2010 elections. Mangudadatu said in an interview with the media following the release of the verdict at the Camp Bagong Diwa in Taguig City. “Ang gusto ko nga talagang bitay, lalo na ‘yang si Unsay pati ‘yung magkakapatid dahil grabe ang ginagawa nila. Hindi lang Maguindano massacare ang ginawa niyan,” MANILA – The convicts of the 2009 Maguindanao massacre must not only rot in jail but should be sentenced with death penalty, Maguindanao Rep. Esmael “Toto” Mangudadatu said. Mangudadatu also said that the verdict handed down by Quezon City Regional Trial Court Judge Jocelyn Solis-Reyes will gauge the strength of the country’s judicial system. “Ang importansya ng verdict ngayon, sa isang dekadang paghihintay, ay para makita ng taumbayan na may batas tayo, kumakagat pa rin ang batas at mahinto na rin ‘yung sobrang pang-aapak sa mga tao,” he said. Capital punishment was already abolished in the Philippines since 2006 but Mangudadatu, who is a member of the 18th Congress, is in favor of reinstating the death penalty. “‘Yung mga major crimes na katulad ng ganyan at ‘yung mga rape, itong mga drugs na sobrang dami ng pumapasok sa atin,” Mangudadatu said. The victims were on a convoy heading to Comelec provincial office in Shariff Aguak town to file Mangudadatu’s certificate of candidacy for governor of Maguindanao when they were waylaid and eventually killed./PN
Recently I stated in a blog that Donna Lamping Hoeing would be joining her sister, Cindy Lamping, in the Indiana Basketball Hall of Fame. This is not correct!!Last year Cindy was honored as a member of the All-Star Silver Anniversary team. Donna received this same honor in 2006, and now she is being honored by being chosen as a member of the Basketball Indiana Hall of Fame. She is the first person from Batesville (male or female) to be so honored. Congratulations, Donna. You make us proud!Kurt Comer of Jac-Cen-Del will be honored this year as a member of the men’s All-Star Silver Anniversary Team. Congratulations, Kurt.
Lawrenceburg, Ind.— Four local Dearborn County seniors have been awarded by the AIM Young Professionals of Dearborn County.Zac Cody, senior at East Central High School was awarded a $1,000 scholarship and plans to study wild life and earn a degree in ecology at Purdue University.Kara Newman, senior at Lawrence Central High School earned a $250 Future Leader of Dearborn County scholarship. Kara plans to study neuroscience at the University of Evansville. She has previously earned entry into the physician assistant program.Lawrenceburg High School graduate Holly Nutley was awarded a $250 scholarship, she plans to study interior design at the University of Cincinnati.Alex Smith, graduate of South Dearborn High School was awarded a$250 scholarship. He plans to study elementary education at Franklin College in the fall. He also will be playing hoops for the Franklin College basketball team.AIM Young Professionals of Dearborn County is an organization committed to the development of a highly diverse and enthusiastic network of strong social, professional, and charitable relationships for the purpose of creating awareness of the infinite opportunities in Greater Dearborn County. We are dedicated to assisting the youth of today so they may realize their true potential and assist in their quest to identify their individual path for success.
Skipper Vlaar (knee) and Cissokho (ankle) were not risked in Wednesday’s 1-0 Capital One Cup defeat to Leyton Orient. Jores Okore (knee) is also sidelined although he is only expected to be out for a number of days. Brad Guzan will replace Shay Given in goal after being rested in midweek. Ron Vlaar and Aly Cissokho will return for Aston Villa for the Barclays Premier League visit of Hull. Meanwhile, boss Paul Lambert has revealed striker Darren Bent is not for sale in what appears to be a huge transfer U-turn. The £24million record signing looked to have no future under Lambert when he lost the captaincy in 2012 and was sent on loan to Fulham last season. However, Bent is back in the squad this year, along with former outcast Alan Hutton, with chairman Randy Lerner keen for Lambert to use the top earners rather than waste a wage. And with Christian Benteke and Libor Kozak recovering from serious long-term injuries, Lambert will resist any interest in Bent ahead of Monday’s transfer deadline. “I do expect him to be here at the end of the transfer window,” said Lambert, who has been linked with Manchester United midfielder Tom Cleverley. “You would keep Darren. As I said before, you do what’s right for Aston Villa. “No one will go until I say so. You keep all your players and I don’t see us letting anyone go right now. “Nobody will leave without me saying. I don’t think any player like that will move. Darren’s here and nobody will be going.” Hull’s new signing Michael Dawson could make an immediate debut as the Tigers look to put their Europa League disappointment behind them. Dawson swapped Tottenham for the Tigers on Tuesday, having been on Hull boss Steve Bruce’s radar all summer. In doing so, he followed in the footsteps of sibling Andy, who spent 10 years with the club and represented them in all four professional divisions. When Spurs visited East Yorkshire last season the 30-year-old was told in no uncertain terms he was a poor man’s version of their cult hero, but that all changed when he was paraded on the pitch at half-time on Thursday’ against Lokeren. “It was all light-hearted (last season). Had Spurs not been 1-0 down at the time I might have given the fans a wave, but it was all good fun,” he said. “The reception I got on Thursday night was massive, it was a massive welcome and I am looking forward to repaying them for signing me and I’m sure the fans will be right behind me. “Obviously Andy had 10 years at this football club and had a great career here. He played in every league for them. Now it’s down to me to get on with my own career and perform, and I’m sure he will be here supporting me and Hull City whenever he can. “I’m excited to get started now.” Dawson would be a like-for-like replacement for James Chester, who is suspended after last week’s red card against Stoke. Manager Steve Bruce made six changes for the midweek clash against Lokeren and should restore the likes of Tom Huddlestone, Nikica Jelavic, Andrew Robertson and Tom Ince to his starting XI. Press Association
New Delhi : The fire of India’s own #MeToo movement that engulfed the media and entertainment industry with several women coming out with shocking allegations against bigwigs, has now reached to the Board of Control for Cricket in India (BCCI).On behalf of an unnamed victim, author Harnidh Kaur had posted that BCCI CEO Rahul Johri had allegedly sexually harassed her when he was in the Discovery Channel. The victim claimed to be an ex-colleague of Johri.Also Read | #MeToo: Kate Sharma files police complaint against Subhash Ghai for alleged sexual harassmentFollowing the woman’s allegations, the Supreme Court-appointed Committee of Administrators (CoA) has given him a week’s time to respond to charges.“The reports disclose allegations of sexual harassment made against Mr Johri, by an unnamed person through a twitter handle. The allegations also relate to his previous employment with a large media house,” the CoA said in a statement.The CoA said that it was “appropriate” to seek an explanation from Johri even as the allegations didn’t pertain to his employment with the BCCI. The SC-monitored body, however, said that further course of action will be taken after his explanation.“He has been asked to submit his explanation within a week. The future course of action will be considered on receipt of his explanation,” the statement read.Also Read | Hrithik Roshan’s ex-wife Sussanne Khan says #MeToo is another publicity gimmickThe #MeToo movement in India started after former Bollywood actress Tanushree Dutta’s allegations of sexual harassment against National-award winning actor Nana Patekar. For all the Latest Sports News News, Cricket News News, Download News Nation Android and iOS Mobile Apps.
The team was traveling to New York to resume its schedule against the Yankees in a night game. The Phillies (1-2) have not played since July 26. Their opponent in that opening series, the Miami Marlins, had at least 18 players test positive for the coronavirus. Although the Phillies didn’t have any players test positive, their games last week were postponed as a cautionary measure.ANGELS-TROUT RETURNMike Trout to return to Angels on Tuesday after baby’s birthANAHEIM, Calif. (AP) — Mike Trout is expected to return to the Los Angeles Angels on Tuesday after missing four games to be with his wife and newborn son. Organizers made a similar announcement several weeks ago for the postponed Olympics. The Paralympics open on Aug. 24, 2021, and close on Sept. 5. The Olympics are to open on July 23. Local organizers and the International Olympic Committee have offered few details about how these two massive events can be held in the midst of a pandemic, or even the wake of a pandemic. They say they are trying to prepare for many scenarios that could include quarantines, limited fans, and massive cuts in staffing.FIFA-INVESTIGATIONFIFA: Infantino not reckless for taking no notes at AG talks Associated Press August 3, 2020 Update on the latest sports UNDATED (AP) — A FIFA official says president Gianni Infantino was not acting criminally by taking no notes during secret talks with Switzerland’s attorney general that are now part of a criminal investigation into the head of world soccer. FIFA deputy secretary general Alasdair Bell is defending Infantino’s conduct while claiming not to know the specifics of the meetings, denying his boss had acted recklessly. Bell says Infantino has never denied the existence of meetings with attorney general Michael Lauber to discuss the sprawling investigation into football corruption. Bell says Infantino was meeting Lauber to show FIFA had moved on from the Sepp Blatter era.WISCONSIN-SUPREME COURT-ULTRAMARATHON-INAUGURATIONNew Wisconsin justice sworn in during ultramarathonMADISON, Wisc. (AP) — Talk about killing two birds with one stone. New Wisconsin Supreme Court Justice Jill Karofsky finished her 100-mile ultramarathon after being sworn in mid-run. Karofsky was sworn in around 1 p.m. Saturday at the 35-mile marker of her route in south-central Wisconsin. State Supreme Court Justice Rebecca Dallet administered the oath of office in Basco. Karofsky began running Saturday at 6 a.m. WMTV-TV reports the run took her about 34 hours to complete. Share This StoryFacebookTwitteremailPrintLinkedinRedditVIRUS OUTBREAK-PHILLIESPhillies head to New York with no positive testsUNDATED (AP) — Results of Covid-19 testing conducted Sunday show there were no new positive results for the Philadelphia Phillies. MILWAUKEE (AP) — Milwaukee Brewers officials say bench coach Pat Murphy has been resting comfortably after suffering a heart attack during a Saturday team workout at Miller Park. Brewers general manager David Stearns said the 61-year-old Murphy received a stent and should be out of the hospital later this week. TOKYO-PARALYMPIC SCHEDULETokyo Paralympic competition schedule will be same next yearTOKYO (AP) — Organizers say the Tokyo 2020 Paralympic schedule remains essentially unchanged for the event that has been postponed until next year. Angels manager Joe Maddon says the three-time AL MVP is likely to play in Seattle at the start of a six-game road trip.Trout missed his fourth straight game Sunday after his wife, Jessica, gave birth to their first child on Thursday. The Angels transferred Trout from the paternity list to the restricted list after the three-day time limit on the paternity list expired Sunday. Los Angeles is off today.BREWERS-MURPHY-HEART ATTACKBrewers’ Pat Murphy ‘resting comfortably’ after heart attack
Team Nigeria at the weekend defeated Seychelles 3-0 to finish third at the ITF World Team Cup Junior Qualifying Championship in Tunis, Tunisia.Michael Osewa was the hero for the three-man U14 team as he defeated Damien Laporte of the Seychelles in straight sets to clinch the bronze for Nigeria.The outcome was a sweet revenge for Osewa, who was beaten to the African Junior Championship title in Pretoria in March by his rival from the Indian Ocean Island. Hosts Tunisia took gold to qualify for the World Team Cup billed for Czech Republic in August.“We had a decent performance as we won four of our nine matches in the World Team Cup,” Nigeria’s coach, Mohammed Ubale said on arrival in Abuja Saturday.He added that the team have a good chance to bag qualification next year stressing that the ‘Fulani Boys’ Saminu Abubakar and Musa Sani showed lots of promises.“Despite the fact that they were playing their first international tournament outside Nigeria, they played very well. They have the talent and what they need is a bit more exposure because the matches they lost were due to inexperience.”Abubakar and Sani, in separate interviews, relished their experience vowing to put up better performances for Nigeria next time.They also thanked Prof Amina Mohammed, the Minister of Environment and Prof. Jubril Ibrahim for supporting their tennis careers.Nigeria’s U16 team which featured in the Junior Davis Cup qualifier held simultaneously finished just outside the medal zone which was occupied by Morocco, Egypt and South Africa. The top-two teams qualified for the tournament in Hungary in July.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram